While Mythos is changing the security threat model in some ways, I am not particularly concerned about exploits being found in blue-chip smart contracts. If the code base is small and important enough (most SC code is), then traditional methods are sufficient to achieve high confidence in security. What's changing is the cost of searching for exploits in large codebases. These bugs were always there, but we are compressing the time to discover them. This is largely what is driving the recent infrastructure compromises affecting everyone. With smart contracts, this can be protected against using rate limits and timelocks, limiting the damage that can be done if an off-chain system is hacked. Overall, this is a period of understandable apprehension, but I'm confident that by following best practises we can make it to the other side stronger than before.