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Micaela
@micaelabazo
Joined October 2023
949 Following    1.9K Followers
new update incentivizes NOVA Blueprint miners to develop algorithms that can efficiently discover more novel molecular scaffolds rather than converging around variations of the same ones finding entirely new entry points is where the greatest value creation can happen and could eventually lead to: - first-in-class therapeutics - treatments for diseases with limited or inadequate standards of care - entirely new categories of drugs - and unexplored regions of chemical spaces that traditional pipelines may never reach otherwise
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New NOVA Blueprint update We are making our chemical search competition significantly more exploration-focused. Starting Wed May 20, 2026 00:00 UTC, submissions containing molecules that are too chemically similar to each other will be rejected entirely. Why this matters: In real drug discovery campaigns, the most valuable search strategies are not the ones that generate many near-identical molecules around the same idea. The real challenge is finding multiple distinct scaffolds that perform well. Once you discover a promising scaffold, generating variations around it is relatively easy. What is hard — and far more valuable — is exploring chemical space broadly enough to uncover entirely new starting points. That is why we originally introduced entropy thresholds in Blueprint, and this new update pushes that philosophy further. We are explicitly rewarding algorithms that: - explore broadly - surface diverse chemical ideas - avoid collapsing into narrow clusters of near-duplicates The goal is not just higher scores but rather better chemical navigation strategies for real-world discovery. This update should lead to: * more novel molecular starting points * stronger search algorithms * and ultimately better drug discovery systems #Bittensor# #SN68# #DrugDiscovery# #AI# #DeSci#
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