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Jun Cheng
@s6juncheng
Computational Biology | Machine learning research scientist at @GoogleDeepMind
392 Following    2.5K Followers
We are offering 10,000 scientists the highest usage tier in Google Antigravity free of charge for 6 months. Please apply!
Gemini 4 Argon is now globally available. Built to solve your hardest problems from start to finish, the model brings frontier capabilities across coding, enterprise workflows, and cyber defense.
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Very happy to announce that our team @GoogleDeepmind has pushed the boundaries of generative biology, achieving the successful synthesis of AI-designed proteins that are both functional and watermarked. This proof-of-concept watermarking of the building blocks of life is enabled by SynthID Bio, our new protein watermarking method. It is designed to safeguard the new era of AI-powered generative biology and strengthen global biosecurity. You can read my thoughts here on why watermarking AI-designed proteins is an important research breakthrough:
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🚀Please help share widely! We're excited to launch the new #AI4BIO# #Fellows# Program @SCSatCMU to recruit exceptional early-career scientists pursuing bold, independent research at the intersection of AI and biology. Fellows will be supported by The Center for AI-Driven Biomedical Research (#AI4BIO#) @SCSatCMU and co-mentored by two CMU School of Computer Science faculty members, with opportunities spanning AI models, computational biology, and autonomous science, including engagement with the CMU AI Science Foundry ( We are looking for truly exceptional candidates who want to help define new directions for AI-driven biomedical discovery. 📅 Apply by November 15, 2026. 🧬 Program information: 🤖 Application via Interfolio:
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We’re hiring in my group at Calico. We build Borzoi and its successors—deep learning models that predict how every nucleotide shapes cell-type-specific gene regulation—and apply them to interpret human genetic variation.
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Great to see this, congrats!
Scaling laws are powering AI. It’s time to scale biology. Today we’re launching the Virtual Biology Initiative to generate the data to unlock scaling laws in biology and build accurate predictive models of the cell. Digital representations of proteins are already expanding our understanding of life at the molecular level, and accelerating the design of molecules and medicines. Accurate digital representations of the cell could reveal the mechanisms that are responsible for disease, and show how to reverse them. The protein data bank, and worldwide repositories of protein sequence biodiversity were created through decades of work by the scientific community. The advances in artificial intelligence for proteins would not have been possible without them. The cell is orders of magnitude more complex, and we will need to create the data in just a few years rather than decades. This will require a coordinated global effort. We're partnering with Broad, Wellcome Sanger, Arc, Allen, Human Cell Atlas, Human Protein Atlas, NVIDIA, and Renaissance Philanthropy. Biohub is contributing to this effort as both a funder and a builder. We are developing microscopy to observe millions of cells in living organisms, and cryo-ET to resolve the cell in atomic detail. We're building instruments that expand the range of modalities and parameters that can be simultaneously measured. We’re developing molecular, cellular, and tissue engineering to create models of disease and design interventions. The data we generate will be available to the worldwide scientific community. We’re also committing $100M over the next five years to support work beyond Biohub. We invite other scientific teams and funders to join. Link:
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Join us at #AIxBIO# 2026🧬8-10 June, Wellcome Genome Campus UK! We have amazing lineup of speakers and scientific committee. From gene regulation to protein design to drug discovery, abstract deadline 27 April.
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Excited to co-host #AIxBio# 2026 (8–11 June) at @wellcomegenome / @sangerinstitute in Cambridge, UK! Join an amazing speaker lineup alongside co-hosts , @ferruz_noelia, Jun Cheng, Jussi Taipale @BenLehner, @deboramarks, The conference will explore five themes: 🔬 Solving the gene regulatory code 🧪 Solving proteins — data, structure and design 💊 Solving chemistry and therapeutics 🫀 Solving cells, tissues and organs ⚙️ AI methods development Abstract submissions are open — deadline 27 April 2026. Selected abstracts will be featured in the main programme alongside invited talks. Register and submit your abstract here: #AIxBio# #AI# #Biology# #MachineLearning# #Genomics#
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@Nature's @ewencallaway writes about how hackathons using AlphaGenome are solving rare disease mysteries. "The event helped diagnose someone with a rare condition called Rothmund–Thomson syndrome... [which] affects eyes, skin and other organ systems." Discoveries like this are why we @GoogleDeepMind believe advancing science is one of the most meaningful motivations for developing AI. Read more:
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AlphaGenome paper and models are out today! We have seen great community engagement since we released the API. We hope to open more use cases with the model weights! We updated the supplementary note with some very interesting case studies. I encourage everyone using AlphaGenome for non-coding variant interpretation to read it. It was a huge team effort, I’m very proud of all of our co-authors @googledeepmind!
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This is a great idea, congratulations!
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. I'm excited to share our new work combining genetic associations and Perturb-seq to build interpretable causal graphs, out today in @Nature:
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Excited to launch our AlphaGenome API along with the preprint describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @GoogleDeepMind
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Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
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