A preclinical analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to #oxphos# curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. @MayoClinic

A preclinical @SciSignal analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to #oxphos# curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions.

Inflammaging: Experimental Insights and Translational Advances 🔥 "Preclinical interventions demonstrate that inflammaging is modifiable through senolytics, which selectively eliminate senescent cells, and senomorphics, which suppress SASP without inducing cell death...👇 Metabolic modulators such as metformin and rapamycin attenuate inflammatory signaling, while immune-directed therapies and microbiome-targeted interventions provide synergistic benefits through combinatorial approaches. Early-phase clinical trials in frail older adults show feasibility, safety, and preliminary efficacy, including reductions in circulating inflammatory markers, improved physical function, and enhanced immune responsiveness. Inflammaging trajectories are shaped by lifestyle, environmental exposures, and evolutionary factors, underscoring the need for personalized interventions."

EXCLUSIVE: Sunshine Biopharma ($SBFM) updated its K1.1 mRNA cancer program, with preclinical work showing tumor-suppressing activity in liver cancer models. Next, it plans to test K1.1 mRNA with a cancer vaccine for non-small cell lung cancer.

The Miami longevity startup says it hopes to reach human trials during the nine-month program, after extensive preclinical development. #longevity# #humantrials# #preclinical# #Miami# #startup#

Anthropic has opened a Bay Area wet lab, moving biology work from computer models into physical experiments. The facility is preclinical and not specifically for drug discovery. Anthropic's safety rules now have to follow Claude into real lab work.

🚨 New research shows fructose, helps cancerous tumors spread. When chemotherapy damages ovarian cancer cells without completely destroying them, some enter a state known as senescence, where they stop dividing but remain biologically active. A new preclinical study from The Wistar Institute has revealed that these surviving cells produce and release fructose, which neighboring cancer cells readily absorb. This absorption alters the way target cells process energy and dramatically lowers cholesterol in their outer membranes. Since cholesterol acts as a vital cellular glue keeping cells anchored together, this depletion allows neighboring cancer cells to detach and easily spread throughout the abdominal cavity. In animal trials, mice given high levels of fructose in their drinking water developed significantly more metastatic nodules than those given glucose. Furthermore, clinical samples from patients with high-grade serous ovarian cancer showed a correlation between elevated circulating fructose levels and advanced stages of the disease. While researchers caution that these preclinical findings do not mean eating fresh fruit causes cancer to spread—as whole fruit contains fiber and other vital nutrients—the discovery opens a promising new avenue. Scientists are already investigating if this fructose-driven mechanism also fuels the progression of pancreatic, colon, and liver cancers. source: Cole, A. R., et al. (2026). The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming. Nature Aging.