(former?) wet lab scientist/mAb engineer here: hypothesis generation was never a major blocker to developing new drugs/advancing science. It's easy to generate low-quality hypotheses. You can waste years chasing bad ideas
It's much harder to ID the good ideas and determine how to best test/implement them with reasonable time and cost
Borrowing from
@mfgrp & the late Chris Walsh: often the problem choice constrains feasibility and impact