Every waking moment of Steve Jobs's adult life had been spent building Apple. When it was taken away, he had no real friends and no other life to turn to, so he simply vanished for a while, and nobody knew where he'd gone or whether he'd return.
At the lowest point, Steve Jobs has to close down the hardware division.
That's the moment he realized "that he's alone and almost a complete failure in business."
It's also the moment everything changes