Arc Institute
@arcinstitute
A full-stack institute for AI and biology research.
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Today in @ScienceMagazine, we report the first functional AI-generated genomes. 🧵
One of our most popular preprints of 2025 is now published in @ScienceMagazine. Congrats to @BrianHie, @samuelhking, and team on establishing a framework for generating and evaluating AI-generated genomes.
- Access the paper:
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In a new preprint from @brianhie’s lab, the team reports the first generative design of viable bacteriophage genomes.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
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The Proto team from @BrianHie's lab will be at the re:AGENT hackathon, a two-day weekend (8/15–8/16) in San Francisco for people interested in building AI scientists, datasets, or pipelines for biological design.
Apply by Thursday, July 30th, 12 PM PT at
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Congrats to Science Fellow @zhou_jingtian and team on their human epigenome atlas, now out in @ScienceMagazine. They show that grouping cells by DNA methylation or chromatin structure yields different subtypes in some lineages but not others:
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New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)
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We are hiring for a number of AIxBio positions across the organization, including Directors of Machine Learning for each of our Institute Initiatives and postdoctoral fellows focused on ML for Biology and Biological Design in @pdhsu's lab. Learn more or apply here:
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Together with @BrianHie's lab, we are looking for a lab manager to join the team @arcinstitute. If you love to organize, optimize, and accelerate scientific discovery, please consider applying!
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Start assembling your team because the 2026 Virtual Cell Challenge officially kicks off on Thursday, August 20.
This is round two of our global competition to understand and predict how cells respond to internal cues and external stimuli.
Expect a new problem to solve, a wider range of metrics, and a $100,000 grand prize.
We look forward to sharing more details at launch.
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Imagine programming protein, DNA, and RNA systems like you would write computer code, or even by natural language prompting of an AI agent. @brianhie and team just made this a reality with Proto: a high-level programming language for generative biology.
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In a new preprint from @brianhie’s lab, the team reports the first generative design of viable bacteriophage genomes.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
Show more
New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)
Show more
