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kevin horgan
@kevinhorgan
microbiome, biomarkers, algorithmic biology - convergence inspired by Sydney Brenner's 1971 statement "in biology explanations will be algorithmic explanations"
3.4K Following    702 Followers
@nntaleb @bryan_johnson Data supporting your point - Rutledge GA Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement? Rejuvenation Res. 2021 Oct;24(5):331-344. doi: 10.1089/rej.2020.2361. Epub 2020 Oct 20. PMID: 32924860.
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This is the most overtly religious World Cup ever - Germans and Curacaoers praying together on the field after the 7-1, Holland's prayer circle, and after I wrote this Lamine Yamal did the Sujood after scoring. What are we seeing? Me @FT, free to read
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The textbook explanation for NSAID gut toxicity? Wrong. Two new studies show the gut microbiome, not prostaglandin suppression, drives GI injury. The microbiome can no longer be an afterthought in drug development. #microbiome# #pharma# #drugdiscovery#
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Research Analyst @Shea_ARK shares her top 3 takeaways from the Multiomics section of ARK's Big Ideas 2026 report.
Just had very pleasant experience at #Porto# airport, preparing for flight to #CPH# #ryanair# staff professional, efficient and friendly. Kudos!
Enthusiastically recommend Michael Rose's substack - Introduction to the Evolutionary Biology of Aging If you are interested in aging and health, cannot think of a better resource.
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Not your bartenders IPA, here reduction of gut inflammation by metabolic reprogramming of CD4+ T cells toward the enhancement of mitochondrial respiration. #microbiota#
Netherlands is the reason we are able to use AI. Not the U.S., Not China. Not even Nvidia. One Dutch company controls the machines that create every AI chip on Earth. Here's how this one company created a monopoly no one can break:
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Brilliant insight from @mkblyth
And also, I got to have a right good rant about pretty much everything from the likely geopolitics of MAGA to the US (not) going bankrupt on NPRs @onthemedia last week. If you like me in full effect and unfiltered, this is it:
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Is it Gulf of Mexico or Gulf of America? If your answer is “Mexico” do this:
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If the people doing this, from @elonmusk on down, are honest about their intentions, they should have zero problem publishing EVERYTHING they are doing on a daily basis i absolutely want to see @Doge reduce wasteful spending. But i want the process to be transparent.. I don't want to have to guess which media reports are accurate or not. If this is the result of a detailed plan. I want to see the plan. If this is legal. I want to see the law that supports it. If there are questions about whether it is, I want to see the opposition. This isn't a shock and awe attack on foreign soil. This is a shock and awe attack on American Systems and Economics. That doesn't mean it shouldn't happen. But if it should, then it should be 100 pct transparent. If they hide anything, they are doing it wrong. If they hide anything, that means the goals is not the interest of the American People. We were promised transparency. We should see everything
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Low capital gains taxes, especially on long term investment in innovation, incentivize investment and create jobs. Obama’s original plan that was never implemented had capital gains on innovation investment at zero in some cases. Makes total sense to incentivize investment in societal goals like curing disease, winning in AI, and fixing the climate via tax policy. And it probably increase tax inflows in the long run. Kind of a no brainer.
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Why has fertility recently plummeted in the US and other rich countries? Seems financial insecurity overhang from 2008 crisis is a plausible explanation - @KTmBoyle Any better analysis elsewhere?
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Thanks for posting
May your outer dignity mirror an inner dignity of soul. This poem by the late John O’Donohue is so alive and beautiful, and it is perfect for the start of the year (though how can we already be nearing the end of January?). We have so much power inside of ourselves, every one of us. What can we do to tap into the call of our gifts (or what Howard Thurman might call the “sound of the genuine”) to break through the noise all around us and follow our unique path on a shared road to more dignity for all? I am learning the power of presence, of quiet, of listening not only to the voice we are here to serve, but to the wise voices from past generations that live inside. To find that place of quiet requires presence, quiet, wonder, paying deep attention, finding a moment of beauty in the chaos. Ultimately, we will transform the world only when we are brave enough to transform ourselves. And if uncertain times make that feel harder than ever, so do they make the quality of presence and of listening more important.
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Pulitzer-winning cartoonist @AnnTelnaes has resigned from her position at the Washington Post after she says her cartoon depicting Bezos and other billionaires on bended knee for Trump was killed. Her piece here:
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As a virologist, I encourage everyone to listen to @ScottGottliebMD’s advice on how we can better prepare for a possible flu pandemic. As an investor, I hope the US makes the appropriate investments. We have better tools now than we did for COVID. Diff virus, diff tools.
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President Carter’s passing leaves a hole in the moral leadership of the world, at a time when it is needed more than ever. He was one of the guiding lights of my life, and one of the most impactful leaders of our time:
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The most important technical concept in AI in recent years was introduced by group comprised mostly of immigrants. The most important technology in the 21st century is largely coming out of the US today due to immigration. America should not take this for granted.
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Paper looking at off-grid solar power for data centers. 100% solar+batteries is still way more expensive than gas, but ~50–90% solar+batteries backed by gas is close to gas in price. (How much further do PV/battery prices have to fall for some combo to beat gas alone?)
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