Meet Biotech’s kingmakers. RA Capital and OrbiMed each led at least 10 private biotech rounds over the last five years, more than any other investor in our cohort. One firm led 6 rounds across just 7 companies. This is the power map behind Biotech in private markets. 🧵

Raising in crypto? A lot of the funds you'd pitch from the 2021 cycle don't write checks anymore. These 14 are still deploying in 2026. @variantfund : Variant. Pre-seed/seed, leads the earliest round. DeFi, AI x crypto, agentic finance. Just closed $222M (June 2026). @archetypevc : Archetype. Seed, leads. On-chain social, payments infra, crypto AI. $100M Fund III. @PortalVentures : Portal. Pre-seed first, $1–10M, leads. Bitcoin ecosystem, modular infra, RWAs. @hack_vc : Hack VC. Pre-seed/seed, ~$1–3M, leads. Web3 AI, infra, DePIN. @6thmanventures : 6MV. Pre-seed to Series A, up to $5M. Solana-heavy: consumer, gaming, AI agents. @lattice_fund : Lattice. Pre-seed/seed, $500K–$1M, leads day one. Generalist crypto. @coinfund: CoinFund. Seed to Series A, $500K–$15M, leads. DeFi infra, stablecoins, decentralized AI. @EV3ventures : Escape Velocity. $500K–$3M, leads. Closed $62M Fund III (Jan 2026). @egodeathcapital : Ego Death. Series A, $3–8M. Bitcoin only. $100M Fund II. @dragonfly_xyz : Dragonfly. Early stage, leads. Closed $650M Fund IV (Feb 2026), deploying straight into the downturn. @a16zcrypto : a16z crypto. Pre-seed to growth. CSX accelerator is the front door ($500K). Crypto Fund V, $2.2B. @paradigm : Paradigm. Seed to Series B, leads. Raising a $1.5B frontier fund. @HaunVentures : Haun Ventures. Seed to late, leads. Just raised $1B, now chasing crypto x AI agents. @PanteraCapital : Pantera. All stages, leads ~85% of new deals. Oldest US crypto fund, Fund V ~$1B. Save it and pitch accordingly.