As I just posted, you cannot stop the advance of AI. If you try to pause AI data centers here, plenty of places want them built, like Malaysia or Kazakhstan, and India & many others would surely be delighted to have these investments too. Be smart, America, don’t mess this up!

I’ve seen things you people wouldn’t believe. Attack ships on fire off the shoulder of Orion. I watched C-beams glitter in the dark near the Tannhäuser Gate. All those moments will be lost in time…like tears in rain. Time to die. Roy Batty (from Blade Runner)

This is how unbelievably good Gemini 4 Carbon is! The funny irony is that the stupidity index of those who just sold their Google shares is proportionate to Carbon's intelligence score!😅 Only two things may be infinite in the universe: machine intelligence & human stupidity! 🤣

Yes, Longevity IS coming! Just don’t die for the next 5-10 years to make it to longevity escape velocity (LEV). Once we reach LEV, then every year you live will begin to add an additional year to your lifespan until we reverse aging in ~15 years. After that, longevity will be defined as 100s of years!

Throughout my life, I’ve been fortunate to know people far smarter than me. My scientific mentors, whom I deeply revere, are among the most brilliant minds I’ve ever known. That’s precisely why I’m so excited about AI & value it so deeply. It has already become my mentor & will soon surpass greatest human minds!❤️

My “irrational” conviction for the past quarter century: solve aging, reverse it & extend human lifespans to hundreds of years. In the age of AI, it’s time to double down on that conviction!☺️ By the way, Vinod & Khosla Ventures have been instrumental in backing seemingly audacious visions 🫡

I feel incredibly privileged to be alive at the most extraordinary moment in human history, and even more honored and humbled to contribute, however modestly, in the age of AI and at the dawn of the superintelligence era! My deepest gratitude to @OpenAI for this opportunity to share my excitement for an incredible future! 🚀 After a lifetime devoted to science, I can think of no greater purpose than helping harness this extraordinary new intelligence to accelerate discoveries, conquer diseases, and build a better future for humanity! 🙏 Live long and prosper! 🖖

This is how unbelievably good Gemini 4 Carbon is! The funny irony is that the stupidity index of those who just sold their Google shares is proportionate to Carbon's intelligence score!😅 Only two things may be infinite in the universe: machine intelligence & human stupidity! 🤣

This is just incredible! Google Gemini Carbon AI model is now No. 1 in v5.0 of the Artificial Analysis Intelligence Index! This new version eliminates most benchmaxxing concerns, so this is the real thing! As I said, “never bet against Google!”

The thing is, even most people using today’s AI models & products have no idea what’s coming, how insanely better things will get, or how much faster they will accelerate! We’ve reached intelligence escape velocity, & everything is about to get crazier than ever!

Truly incredible short AI film! We're only limited by our imagination now, and of course still need intense talent like PJ to pull this off! In a year, it will likely cost a tenth of what they spent, and we'll start seeing full-length AI movies!

What?! 🤯 In the future, all surgeries will be performed by robots with AI agents! They will be much more precise and safe. Human surgeons may still be in the loop for some time, though. “Last night an AI agent performed brain surgery on a mouse. We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorized surgery rig with cameras, and one goal: reduce seizures.”

Yes, Longevity IS coming! Just don’t die for the next 5-10 years to make it to longevity escape velocity (LEV). Once we reach LEV, then every year you live will begin to add an additional year to your lifespan until we reverse aging in ~15 years. After that, longevity will be defined as 100s of years!

Why I believe AI / SI will unlock cures for every Cancer within the next five to ten years ears - PART 1: For decades, cancer researchers have confronted a seemingly impossible problem: the biological complexity of cancer is so enormous that no individual scientist, research team, or even the entire scientific community can systematically explore all possible therapeutic solutions. Consider what happens inside a single tumor. Thousands of genes, proteins, metabolites, and signaling pathways interact across millions or billions of cells. Then cancer cells constantly evolve, acquiring mutations, adapting to their environments, escaping immune surveillance, and developing resistance to treatments. Their behavior is further influenced by surrounding immune cells, blood vessels, fibroblasts, and the metabolic conditions within the tumor. And every patient's cancer is different. This creates an astronomical number of possible biological states and therapeutic interventions. Even when scientists identify a promising molecular target, they must determine whether interfering with it will actually kill the cancer, whether healthy tissues depend on the same mechanism, and whether the tumor will eventually escape. Historically, we’ve approached this problem through relatively very slow cycles of hypothesis generation, experimentation, and clinical testing. We investigate a limited number of targets, screen a fraction of possible compounds, and spend years determining whether a treatment works. Now imagine what happens when the intelligence available to solve these problems increases exponentially. I believe the next five to ten years will bring superintelligence systems whose scientific reasoning, computational modeling, and experimental capabilities will vastly exceed those of today's best researchers put together! The implications for cancer research will be profound. Here is the part 1 of how this can be achieved: Virtual cells: One of the most exciting developments will be the emergence of virtual cells, or computational models designed to predict how living cells behave and respond to interventions Imagine an AI system that can represent a cancer cell's molecular machinery, including its genetic mutations, gene expression, protein interactions, metabolism, and signaling networks. Instead of testing one drug at a time, scientists could ask the model what would happen if they inhibited a particular protein, activated a specific immune pathway, edited a gene, or administered several treatments simultaneously. Now extend that capability to millions of virtual cancer cells representing different tumor subpopulations, together with immune cells and healthy tissues. We could potentially simulate how an entire tumor responds to treatment, how resistant populations emerge, and how different interventions affect normal cells! This is the vision of increasingly comprehensive biological foundation models: AI systems trained on extensive molecular and experimental data that learn generalizable principles of cellular behavior. The extraordinary opportunity is that such systems could eventually discover therapeutic mechanisms that we have never considered because we lack that computational capability. They might identify previously unrecognized combinations of molecular vulnerabilities, predict how to overcome resistance, and design interventions that exploit subtle differences between malignant and healthy cells. Today's virtual-cell models are still very limited approximations of biology. But their predictive accuracy and scope will improve dramatically, and they will become powerful engines, accelerating precise therapeutic discoveries by magnitudes faster! Part 2 will be about the digital twins. To be continued.

This is an excellent article on the end of pure mathematics as a field and a new beginning for applied math. Mathematicians who are sour about AI solving all the math problems should read this carefully and stop being pure math intellectual snobs. Those days are over; there is a new dawn for humanity. “New incentives can be designed around problems that genuinely matter for better human life, for individual and social health, for planetary flourishing. And we are not short of those problems. Viewed from the generative encounter model of mathematical progress, a true golden age of mathematics, rooted in human purpose and new visions of education and collective reward, may have just begun.”

Unbelievable new AI model Gemini 4 Carbon from @GoogleAI! It beats Astra and Opus 5.5 on science, math, cybersecurity, and agentic coding! As I wrote before, “don’t bet against Google!”

Humanity’s Last Great Invention: The Beginning of Everything Else I went all in on AI several years ago, based on a simple first-principles thinking and a profound realization: virtually everything humanity has ever created, from our technologies and scientific discoveries to our industries, institutions, & the entire global economy, is ultimately the product of human intelligence. Think about it. Every invention, every factory, every medical breakthrough, every business, and every technological advancement began with human minds figuring out how to understand, manipulate, and transform the world around us. Intelligence is the fundamental engine behind civilization & economic progress. Now imagine new super intelligence that surpasses human intelligence across virtually every domain, can be replicated millions or billions of times at a fraction of the cost of human labor, operates continuously at millions of times faster than us, and improves its own capabilities. Then combine that intelligence with increasingly capable billions of robots that can perform every imaginable physical work. The civilizational implications are almost unimaginable! For the first time in history, intelligence itself will become an abundant, rapidly expanding resource. Scientific discovery, engineering, manufacturing, medicine, agriculture, and virtually every other industry will advance at rates previously impossible. AI will increasingly design better technologies, improve production processes, and accelerate further AI development, creating powerful feedback loops of innovation & economic growth. My prediction is that within the next few decades, AI systems & robots will perform more than 90% of all economically productive work, measured in human-equivalent labor hours. This means that the overwhelming majority of tasks required to produce goods & services will eventually be performed autonomously, with humans increasingly determining goals, priorities, & how the resulting abundance is used. And here is the crucial economic implication: the global economy would not simply be today’s economy with fewer human workers. It would become an economy several times, potentially even orders of magnitude, larger in real terms, at the level of quadrillions of $ value as AI dramatically expands our capacity to discover, invent, build, and produce. Of course, intelligence alone cannot eliminate physical constraints such as energy, materials, and infrastructure. But increasingly intelligent AI will also greatly help us overcome many of these bottlenecks through better engineering, automation, and scientific breakthroughs. We have spent thousands of years building civilization with the limited intelligence and labor of human beings. We are now approaching an era in which both intelligence & physical labor could become massively scalable. That changes the fundamental economics of civilization itself. And we are only at the very beginning of what will become the greatest economic, scientific, and technological transformation in human history. My message to everyone is simple: Do not underestimate what is coming, it’s much larger than even most optimistic projections, and do not remain a passive observer of this greatest transformation in human history. If you are a scientist, use AI to accelerate discovery. If you are an entrepreneur, build companies that solve problems previously considered impossible. If you are an educator, prepare the next generation for a world of abundant intelligence. If you are a student or professional, start mastering these tools today and go all in on abundant intelligence. And if you are shaping public policy, help create the conditions for this extraordinary new productive capacity to benefit humanity as widely as possible. We have an unprecedented opportunity to accelerate the discovery of cures for diseases, extend healthy human lifespans to hundreds of years, eliminate much of the scarcity that has constrained civilization, expand access to education and opportunity, and unlock entirely new frontiers of human creativity and exploration So my call to action is this: Go all in on understanding AI. Learn it. Use it. Build with it. Rethink every assumption about what is possible in your field. And most importantly, help shape the future you want humanity to experience. The next few decades could accomplish more than all of human history combined. We are not merely witnessing the next technological revolution. We have the opportunity to help build an entirely new era of civilization. The future is being created right now. Don’t just watch it happen. Be one of the people who builds it!

This is just incredible! Google Gemini Carbon AI model is now No. 1 in v5.0 of the Artificial Analysis Intelligence Index! This new version eliminates most benchmaxxing concerns, so this is the real thing! As I said, “never bet against Google!”