I’d personally rather defy any ban on AI & risk spending 20 years in prison than accept a future without superintelligence. Since stopping its development would amount to a death sentence for most of us anyway, with no hope of curing aging. We must resist tyrants like Sanders.

A small reason to be fast is saving millions of lives, but no worries: we should slow down so Terence Tao can still feel important & valuable in math. This sort of attitude to AI from scientists causes me to lose my respect for them. Tao is becoming one of them unfortunately…

OMG! 🤣🤣 This is unbelievably good! The best AI video I’ve watched! The characters are perfect, the whole thing is hilarious, and you can feel the Force! 🤩 Resist the dark side! Join the Rebellion! FREE AI!✨ May the Force be with us!

I completely agree with this take related to the “AI will create viruses that will kill us all” BS. But let me add my few cents, because I am really really angry! I worked with one of the deadliest viruses in history, HIV, for two decades. I was one of the early scientists to engineer it, and engineered versions of HIV are now helping cancer patients. I understand the immune system that defends us against viruses extremely deeply. I have worked in high security biohazard labs. I don’t have a PhD in AI, but I have been involved with AI since the early 90s and have been all in on AI for years. People claiming that you can just make a virus in your garage, use AI to engineer it, and somehow build a virus that will kill everyone don’t know what the hell they are talking about! Of course bioweapons are extremely dangerous. In fact, viruses and bacteria have killed more humans throughout history than almost anything else. HIV alone killed tens of millions of people, yet today, if you have access to effective medicines and take them properly, HIV is generally no longer a death sentence. COVID-19 killed millions. Why doesn’t it kill at anything close to the same scale anymore? Not because the virus disappeared. It is still here. We developed collective defenses against it through our immune systems, prior exposure, vaccines, treatments, and better medical care. And this is exactly the point. The best way to fight biological threats, whether natural or synthetic, is to use AI to develop vaccines, treatments, antibodies, antivirals, and eventually engineer our immune system to create much stronger defenses against them. By the way, it is already possible to make synthetic viruses. You don’t need some hypothetical superintelligent AI model to do that. We have had sophisticated molecular biology and genetic engineering for decades. So how many people have actually died from synthetic viruses compared with natural viruses killing millions every year? And if someday there really is an AI capable of making some unbelievable “supervirus,” then why the hell wouldn’t that same AI make it even easier to develop defenses against it? Or cure diseases, for that matter? Where is this damn superintelligence that has cured a single major disease?! These AI companies and AI doomers keep talking like, “OMG, AI is going to become so unbelievably powerful that it could kill all of humanity!” Then why is nobody asking the obvious question? If your AI is already becoming this godlike, unbelievably powerful intelligence, why hasn’t it cured anything? I mean ANYTHING. Where is the cure for cancer? Where is the cure for Alzheimer’s? Where is the cure for aging? Forget those. Where is the vaccine that prevents the common cold? You are telling me this intelligence will soon be smart enough to engineer some magical virus capable of wiping out 8 billion people, defeating every immune system, every vaccine, every antiviral, every laboratory, every government, and the entire global biomedical community… …but somehow it still can’t cure one disease? I call that greatest intellectual dishonesty ever! At least WE actually know how to cure things and save millions of lives with our supposedly stupid human intelligence compared with this future “superintelligence.” Humans eradicated smallpox, which killed hundreds of millions of people throughout history. We turned HIV from a almost certain death sentence into a manageable disease. We developed vaccines in record time against COVID. If we had the same AI back then, would have saved millions more! We engineer immune cells to kill cancer. We developed antibiotics, antivirals, monoclonal antibodies, gene therapies, organ transplantation, and thousands of medicines. We aren't fast enough but we did all of that with our ordinary human intelligence. So imagine what actual superintelligence could do for medicine! And here is the part that really makes me angry. If you actually have, or are close to having, an AI capable of curing diseases and saving millions of lives, and you are deliberately slowing it down or refusing to make those capabilities available, then we also need to talk about the human cost of THAT decision, which you fearmongering people are going to be responsible for! More than 150,000 people die every single day around the world. Every. Single. Day. More than 90% from Cancer, heart disease, infections, aging. How many die because of AI? ZERO! Talk about the people dying TODAY. Talk about curing cancer. Talk about stopping the next pandemic before it starts. Talk about developing universal vaccines. Talk about engineering our immune system so viruses become almost irrelevant. Talk about curing genetic diseases. Talk about reversing aging. Talk about saving millions and eventually billions of lives. Instead, we constantly hear this “AI WILL KILL US ALL!” crap, delivered with absolute certainty and with this smug smile on your faces in front of cameras, as though imagining a science fiction extinction scenarios. I am actually angry about this. Each one of you causing a delay in AI advance every single day will be personally responsible for those 100 thousands deaths that could have been prevented! Because if you truly believe intelligence is about to become this powerful, then the greatest question humanity should be asking is NOT: “How could this intelligence hurt us?” It should also be: “WHY THE HELL AREN’T WE USING IT TO SAVE EVERYONE WE CAN?” And if superintelligence really is coming, then make sure one of the first things we do with it is make humanity biologically damn near impossible to kill.

One of the greatest intellectual dishonesties of the AI age is assigning an “X% chance” that AI will kill everyone and presenting that number as science! 10%? 20%? 50%? Show me the damn data! Show me the model. Show how you calculated it! Instead, we get chains of speculative assumptions and science-fiction scenarios, including implausible claims about engineered pandemics. I have worked with viruses for decades; biology does not work like a doomsday screenplay. The burden of proof belongs to the person making the extraordinary claim. Nobody else has to prove the probability is zero. If I claimed there was a 10% chance aliens would arrive within ten years and destroy Earth, you would ask where the 10% came from. Possibility and probability are not the same thing. It may be possible that there are million intelligent civilization in our galaxy or none, there is no probability you can assign to that without making wild assumptions. Ask the same of AI extinction. A subjective fear does neither become science because you attach a percentage to it nor make you a credible expert!

Sometimes you realize that your heroes were not the people you thought they were, while those you never expected quietly prove themselves to be the real heroes. And sometimes what shatters is not the hero, but the part of you that believed in them. That hurts more.

AGI is AI capable of matching or exceeding the general cognitive abilities of most humans across nonphysical tasks, including reasoning, problem-solving, learning, and creativity. In my view, Astra has fully crossed that threshold, although we already had “baby AGI” by late last year. ASI, is AI that surpasses even the most brilliant human minds, past or present, with the potential to ultimately exceed the collective intellectual capabilities of humanity as a whole.

I wanted to try something quick with Muse Spark 1.3, so I had it build this pirate platformer. It was incredibly fast and worked flawlessly at one-shot! Now I’m enhancing the artwork, sprites and adding new levels 😊This is such a fun coding model, it just works, fast and cheap!

AI capability vs. reliability is an extremely important issue. @sayashk makes a critical point by measuring reliability with different benchmarks (ex. agent accuracy rates) and finds reliability improvement greatly lags capabilities. AI labs should focus more on reliability now.

The biggest mistake made by almost everyone who claims that curing every disease within a decade, or accomplishing other insanely difficult things like reversing aging in such a short time, is impossible, is assuming that progress over the next 10 years will look something like the past 20 years, perhaps just a little faster. Yet, it will be radically different: the next decade will bring more technological progress than the entire past century. Just think of all the progress we had since 1900 to today happening in the next 10 years or so. That means many things people assume are still 100 or 200 years away could become possible within the next 10–15 years. By 2050, we will likely see more scientific and technological advancement than humanity experienced during the previous 5,000 years of civilization combined! This is the essence of the technological singularity: progress stops feeling linear and becomes so rapid, compounding, and transformative that the future becomes extraordinarily difficult to extrapolate from the past. And that is precisely why the concept is so difficult for people to comprehend, or accept, and also why some of us have such a conviction to keep claiming the impossible!

My perfect Sunday morning: Wake up at 6:00 AM. Get my coffee. Jump into Codex. Launch Live Voice (a.k.a. Jarvis). Discuss and plan with it the next immune/cancer app. Tell Jarvis to start building. Save the world!

I’m super excited for this Builders Unscripted podcast with @romainhuet at @OpenAI. He is a fantastic interviewer & the talk flowed so naturally, completely unscripted! This was also mostly about Codex & how I've been using it in building biomedical apps, with some real demos! ☺️

Fable 5 is back and it’s as useless as before! Hey @AnthropicAI, is this how you support science and presumably relate to and care for humanity? Whatever, I’ve had enough of these nonesense safeguards. I won’t waste any more time with this misanthropic fable!

I’m very excited about this article from @OpenAI on my attempt to use GPT-5 Pro to understand the results of an experiment we did several years ago. Remarkably, GPT-5 Pro figured out the key mechanisms, as explained in the article & infographic below!

Some people are defending Anthropic despite everything that is happening, largely because Fable 5 is an amazing coding model. I can confirm this is true, and I do not think anyone would seriously argue against it. Even its high cost should not be an issue. We live under capitalism, and companies can charge what the market allows. But, and this is a very big but, there is a much more important issue here. What these people do not understand is that Fable will be the best coding model only for a short while. Others are very close behind. In fact, even better models will arrive soon, and coding itself is clearly on the path to being largely solved. Models will then become cheaper over time. If you do not get to build your amazing software a few months earlier, that probably will not change much in the world. At most, it may delay your personal ability to benefit from it for a while. It might even benefit you, by saving you from wasting money and time before better and cheaper versions arrive. But a doctor cannot wait to treat patients. A scientist trying to cure cancer does not have the luxury of waiting months. Every day of delay in research and clinical applications costs lives, potentially thousands of them. Every day that scientists around the world are denied access to the best models is another day the world is delayed from becoming better. And this is not only about model access. Anthropic has also advocated for pauses and regulatory capture. They are strongly against open models. In my view, this is not driven by some pure concern for humanity, but by the fact that such control would give them more money, more power, and more leverage over the future. Therefore, I believe it is far more important to be principled and stand for humanity than to chase short-term personal benefit. That is the reason for my outrage against Anthropic. It is nothing personal against poor Fable 5, or against the great AI engineers at Anthropic who are building these models. I do not doubt that many of them are sincere, and I am grateful to all frontier AI engineers who are pushing this technology forward. But I do hold those in charge of Anthropic responsible. Their founders and leadership should be held accountable for what I see as self-serving and deeply misanthropic actions. I also do not think they care. Not one of them has meaningfully responded to the outrage. This is also a note to everyone who keeps claiming that AI itself is the threat to human existence. No. It is not AI itself. It is the humans who control AI who may become the real threat to humanity, as I have said repeatedly. We have to resist this power capture at all costs, if we truly care about the rest of humanity.