. @talbroda, former VP Compute for @Openai could have joined any fund but picked us. Honored and a real boon to entrepreneurs who take our money. Thrilled have him join @khoslaventures and help back and build the next generation of world-changing companies. As he says "Someone asked me yesterday what success looks like 5 years from now. I think it’ll probably be too early to judge my investment record. But I hope founders will say I was one of the most helpful people around the table, and had a real positive impact on their company. If you’re building in AI, especially AI infra, I’d love to talk! "🚀

“The right agent won’t be an app.” – @vkhosla “Where do most people live? They live in their email, they live in text messaging, they live in Slack.” “The app, if there’s one, is just in the background.” “Meeting a consumer where they are—the consumer experience is really, really important.”

Here’s to you. The ones who believe depression treatment needs something new. Today, our FDA-approved at-home neuromodulation for moderate to severe depression is officially available in the US.

"I only had 5 minutes to read your (medical) chart" @gdb shares a story of his friend in the hospital. @ChatGPT flagged an antibiotic that could have killed her. Her doctor agreed: he missed a detail in her medical history. Need more stories like this to keep the doomers at bay

166,700 fruit fly neurons are walking a robot cat across a desk right now. In September 2026, Google Research and HHMI Janelia mapped every neuron and every connection in an adult male fruit fly's full nervous system, brain, optic lobes, and ventral nerve cord together, and published it in Cell. The number is staggering on its own: 166,700 neurons, roughly 125 million synapses, the most complete nervous system map of any animal ever built. Now that exact wiring is running live, simulated neuron for neuron, inside a small robotic quadruped equipped with a camera and motion sensors. Movement comes in through the sensors, the biological circuitry fires the way it always did, and the output drives the robot's legs directly. No one wrote the balance logic. No one coded the gait. The insect's own nervous system does that job, just on legs it never had. To be clear about what this is and isn't: nothing biological is alive in this loop. It's a full computational reconstruction of real neural wiring, controlling hardware instead of an insect body. The brain is real. The body is borrowed. Remarkable proof that a mapped nervous system can drive any body you give it, or a preview of something people aren't ready to think through yet?

I’ve successfully run the full retained MaleCNS v1.0 fruit fly connectome, all 166,700 neurons, inside Minecraft, with its simulated neural activity driving a fly’s movement. V1 Currently in development. Built with the help of GPT-6 Astra. Props to the @OpenAI team and @thsottiaux for this release. Code and mod coming soon!

Supersonic. Mach 1.21. Quarterhorse Mk 2.1 is now the world’s first privately developed, unmanned supersonic jet and the fastest unmanned aircraft flying today. This flight makes Hermeus the fastest company in aviation history to go from founding to supersonic flight - exactly 364 days after the maiden flight of our first aircraft. Now, we fly faster. A special thanks to @DIU_x, Director @OwenWest91, Maj. Gen. Joe "Solo" Kunkel, and Deputy Director Kyle Norman.