This really hurts my heart. While funny and will get lots of lulz, it's dehumanizing and makes my stomach turn. This is a serious issue, that this makes... I don't know if I can find the word for it. I don't know what to say. Can we create a game now that approves people coming in legally

Playing around with this and I discovered that if I show a photo of my face close up, my attractiveness goes down but my net worth goes up. The further away, my attractiveness goes up and my net worth goes way down. I'm also seen as far left (lol!). I think @Aella_Girl is going to have some really interesting data after this about all sorts of things. Like, for example, I can guess someone is left leaning nearly 70% of the time based on very little.

Not often talked about, are the second and third order impacts of @Tesla's FSD. We think about how many accidents it will prevent, but we don't talk about how the lowering of stress on drivers will impact overall quality of life, which I think will increase substantially. Kind of like a toothache, you don't realize sometimes how much pain you are in until it's gone.

Inspired by @jwmares who was in turn inspired by @patrickc, I ran my old 23andme genome through Claude Code and... also learned some useful things about myself! I pasted Justin's same, simple prompt, and Claude output the five findings that matter most, ranked by how much they should change my behavior. Both of my maternal grandparents had colon cancer, so I kinda suspected as much, but it's still interesting to see an elevated CRC risk flagged in my genomic data. My findings: 1/ You are a poor metabolizer of a large, common drug class You carry one *2 allele (rs1799853 CT) and one *3 allele (rs1057910 AC). Under the CPIC scoring system that's an activity score of 0.5 — poor metabolizer, the bottom tier. About 1–2% of people of European ancestry land here. You also carry one copy of the low-dose VKORC1 allele (rs9923231 CT). This is not theoretical. CYP2C9 clears NSAIDs (ibuprofen, naproxen, celecoxib, meloxicam, piroxicam), warfarin, phenytoin, glipizide/glyburide, and losartan. Standard doses sit in your system substantially longer than they do in most people's — which is a plausible partial explanation if you've ever found ibuprofen unusually effective, or unusually rough on your stomach. The combination of CYP2C9 poor metabolizer and a VKORC1 low-dose allele means that if you are ever prescribed warfarin, a normal starting dose would be genuinely dangerous. This belongs in your chart and on a card in your wallet. 2/ The favorable Alzheimer's genotype — and a reason to stop trusting LDL-C rs429358 TT means no ε4 allele at all. rs7412 CT gives you one ε2. ε2/ε3 carries roughly 40% lower Alzheimer's risk than the common ε3/ε3 genotype — this is the best common APOE result available, and it's about 11% of people. The lipid side is the actionable part. ε2 impairs remnant-particle clearance: it lowers LDL cholesterol while raising triglyceride-rich remnants. Your LDL-C will systematically understate your atherogenic particle burden. If you've been tracking a reassuring LDL number, it's the wrong number for you. Ask for ApoB and non-HDL cholesterol. For an ε2 carrier those are meaningfully better measures of risk than LDL-C, and most standard panels don't include ApoB unless you request it. 3/ Non-secretor — and it explains your gut panel rs601338 AA is the W143X nonsense variant on both copies. You don't secrete ABO blood group antigens into your mucus, saliva, or gut lining. Roughly 20% of Europeans are non-secretors. The consequence that matters: those secreted antigens are a primary food source for Bifidobacterium. Non-secretors characteristically run low on Bifidobacteria and carry a structurally different gut community. If your Tiny Health report flagged low Bifidobacterium, this is very likely why — and chasing it with Bifido probiotics or HMO supplements tends to produce poor, non-durable colonization, because the mucosal niche those strains want isn't there. Two upsides: you're resistant to the dominant GII.4 norovirus strains — genuinely, that's the winter cruise-ship one — and you have lower H. pylori colonization risk. One caution: non-secretor status is associated with higher measured serum B12, so a normal B12 reading is less reassuring for you than for most people. Pair it with methylmalonic acid. 4/ You carry one copy of the celiac-permissive haplotype rs2187668 CT tags a single HLA-DQ2.5 haplotype. You're negative for DQ8 (rs7454108 TT). Around 25–30% of Europeans carry DQ2.5, and it's necessary but nowhere near sufficient — lifetime celiac risk for a heterozygote is roughly 1–3%. This is a door being unlocked, not opened. The one rule this creates: if you ever develop unexplained GI symptoms, iron-deficiency anemia, or unexplained neuropathy, get celiac serology before you try cutting gluten. Eliminating gluten first makes the antibody test unreliable and you'd have to do a weeks-long gluten challenge to get a clean answer. 5/ Elevated risk of colorectal cancer rs36053993 CT at chr1:45797228 is heterozygous for MUTYH G396D, the most common European MUTYH pathogenic variant. Your other MUTYH site is clean (Y179C, rs34612342 TT). Being a single-copy carrier is modest news — roughly a 1.2–1.9× colorectal cancer risk depending on which study you read, not the polyposis syndrome that comes from carrying two copies. --- Pretty much everyone should do this?

Sequencing the first human genome cost roughly $1 billion. Today, sequencing a human genome costs around $100. A billion dollars to hundred in 25 years. One of the most extraordinary cost curves in technology.

5. That was supposed to be my name. They wouldn't let my mother do it. Couldn't spell it either. Would gum up the works. So, Starr became my middle name. It is a family name. Belle Starr, but it's also an object with five points. It's 5 hidden. 5. It's a wonderful number. We have base 10 because of it. We have five fingers (most of us) on each hand. We have five things protruding from our core. We have five main senses. 5. It's a symbol. A representative idea of a number of things, but it's a word. A word that has so much meaning tied to it. Memories. Dreams. 5. Someone saw it in gold on a fire truck, wrote a poem about it, which produced a painting featuring a disguised portrait, representing time and memory and an accumulation of ideas. What does 5 mean to you?

NEVER FORGET: once your culture is gone, it's gone forever. Government education has (deliberately) failed to teach the Great Books of the West for decades. So, we started an independent group to study the Western canon together. We're reading the books that form the mind and shape the spirit. The books our ancestors read. Western Civilization has given us the greatest works ever known, but it takes effort and an open mind to read them. Homer, Plato, Aristotle, Augustine, Dante, Shakespeare, and Milton are not just names in a syllabus, but guides to a deeper and more ordered life. Join our reading group to study the great works in dialogue with others. We read a new classic every 4-6 weeks, and meet biweekly to discuss. We are just starting The Brothers Karamazov, the greatest psychological novel ever written. You do NOT want to miss this. Take out a paid subscription if you'd like to support us and join the discussions directly — it makes a huge difference to the time and resources we can dedicate. You'll get: - Live book club discussions (biweekly) - Access to our incredible community chat - Essays to guide you through the Great Books - All past recordings, essays, and podcasts - Ability to vote on what we read next See you inside!

Applications for the Inflection Fellowship close today, August 14. If you're under 25 and want a fully-funded three weeks to build the magically weird in Goa, this is your last day to apply ⚡ Apply below ↓

Access and proximity in the fashion industry have always shaped which ideas make it out into the world. That's the part we're removing. Fashion Studio gives you tools to: - Turn your sketch into a real life render of your garment - Iterate quickly on ideas for what fabric or color you want - Turn it into a ghostform or flatlay rendering - See it on a model in a photoshoot

@cyantist The best remedy is really asking questions to understand another's perspective the best we can, and to understand their "lens." It's when people make assumptions that their view is the only (obvious) one, that mistakes are made.