Congratulations to @chaidiscovery on its $400M Series C. Chai treats medicine design as an engineering problem, one that can be solved with precision, speed, and scale. Eli Lilly, Pfizer, and Novartis are running its generative design suite, including the latest model Chai-3, against drug targets that have defeated traditional discovery methods. We co-led Chai's Series B, and we're proud to keep backing @joshim5, @jackdent, @Mattmcpartlon1, @j_boitreaud, and the entire team.

Congratulations to @HelsingAI on its $1.8B Series E. Helsing is one of the most consequential AI companies in Europe, bringing AI-native software to defense systems. These capabilities strengthen Europe’s deterrence and enable its democratic institutions to flourish. We’re proud to deepen our partnership with @Gundbert, @torstenreil, Niklas Köhler, and the entire team.

"In what world is hurling half an F-35 at somebody an effective way to deter them?" For decades, a single hypersonic missile has cost as much as $50 million. @hargsb built SpaceX's Starshield business before founding @Castelion to make them affordable at scale, and keep America safe. Watch @AlexaLiautaud in conversation with Bryon. Chapters 00:00 — From South Georgia to Rocket Scientist 05:20 — Watching SpaceX Before Anyone Believed 08:22 — Quitting a Safe Career to Roll the Dice 13:23 — Breaking Into SpaceX 16:42 — Building Starshield and Why He Left SpaceX 22:56 — Peace Through Strength and the Case for Hypersonics 28:14 — The Hypersonics Problem No One Solved 31:10 — The SpaceX Playbook Everyone Gets Wrong 35:58 — Blackbeard's 10-Year Vision 41:50 — Who Succeeds at Castelion 49:00 — Inside the World's Largest Hypersonics Factory

We're proud to invest in @TeamOratomic's $300M Series A. Oratomic plans to build a fault-tolerant quantum computer by the end of the decade, with a simpler path to quantum error correction built on reconfigurable atomic arrays trapped in focused laser beams. This leap could fundamentally transform our world, unlocking solutions to problems like drug and materials design that are computationally impossible today. Congratulations to @DolevBluvstein and the entire team. cc: @AlexaLiautaud

(1/3) America spends ~$5.3T a year on healthcare and ranks last among peer countries on life expectancy. AI hasn't fixed it, because the wins are isolated tools on a broken whole. We're trying something different at Summa Health, in partnership with @generalcatalyst.

We backed @1001ai_ at seed and are continuing to back the team in their $30M Series A. 1001 builds sovereign AI for the critical infrastructure that moves the physical world: aviation, ports, and energy. It's built and governed locally, so operators stay in control. Congratulations to @b_abughazaleh, Mohammed Fituri, and the entire team.

Today we're announcing our $320M Series A at a $2.3B valuation, led by @khoslaventures , with @generalcatalyst, @JeffBezos , @ericschmidt, @NicoRosberg, alongside leading researchers from frontier labs and academia.

Through its agreement to be acquired by @Qualcomm, @Modular aims to accelerate its mission and real-world impact by empowering developers everywhere with production-grade AI software. Congratulations to @clattner_llvm, @iamtimdavis, and the extended Modular team on their journey to make AI’s compute layer unified, efficient, and accessible to all.

"Bad ideas that turn good is where the alpha is." Nearly every investor told @l3amm usage-based billing was a terrible idea, and he built @getmetronome anyway. They saw what others couldn’t at exactly the right time. Metronome became the billing system behind some of the biggest names in AI, and @stripe acquired it earlier this year. Watch GC's @quentinclark in conversation with Scott. Chapters 00:00 — Meeting Scott at Dropbox 01:36 — Why Speed and Correctness Go Together 04:18 — Billing Was the Intern Project 06:09 — Betting Half of Software Goes Usage-Based 10:51 — Rejection Road Trip 12:24 — The Only Term Sheet They Got 16:44 — Refusing to Ship a Wrong Invoice 22:24 — Becoming CEO Overnight 27:06 — When Usage Went Exponential 31:45 — Choosing Customers Who Set the Bar 36:50 — Answering the Stripe Call

“If the technology that helps us be competitive in manufacturing comes from an adversarial country, we have a serious problem.” @standardbots is building the robots that bring American manufacturing back, designed so any worker can train them. We’re proud to double down on their $200M Series C. Congratulations to the entire team. Watch GC's @quentinclark in conversation with @evanbeard. Chapters 00:00 — CRM to CNC 02:52 — What 100 Customers Wanted 05:43 — The Garage Years 12:10 — Start Small to Win Big 14:18 — Closing the Manufacturing Gap 19:13 — Designing for the Worker 25:07 — How AI Changes Robotics 36:47 — Reigniting American Industry 38:09 — “The Making of the Product Is a Product” 39:55 — Should the US Ban Chinese Robots? 43:28 — The Physical AI Moment 48:11 — Robots Everywhere in Five Years 54:50 — Inspiring Tinkerers

Today, Ramp raised $750M at a $44B valuation. Last time we grew this fast, we were 1/20th the size. For 2000 years, business was built on two pillars. Today, a third: intelligence. It’s your least governed cost. It’s also your single greatest opportunity.

Martin Scorsese is an advisor to Black Forest Labs. He's spent six decades shaping how the world sees stories. Now he's helping us shape visual intelligence with human taste and craft at the center. We sat down with him for a working storyboarding session using FLUX.

BREAKING: General Catalyst Releases First-Ever Quarterly Review Hemant Taneja (@htaneja), CEO of @generalcatalyst Is GC going public?? We cover: - GC’s $43B ecosystem - Why the software buyout model is broken - Anthropic’s Series G at $380B - $5B India commitment - Buying Summa Health, hospital in Akron - Anthropic–DoW controversy, Mythos & Project Glasswing - @nikesharora joining the GC board - “Tech Lash 2.0.” HUGE thank you to @deel Co-Founder & CRO @shuooo Wang for the introduction to Reggie & the GC team, I am SO happy we were able to make this happen so quickly! What a treat. 𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒 (00:00) Hemant Taneja, CEO at General Catalyst (01:21) Present state of General Catalyst (05:08) Seed, Creation & the Customer Value Fund (06:54) The purpose behind GC’s quarterly review (12:26) The biggest AI themes right now (15:06) How AI is changing investing decisions (19:25) Why seed & Series G require the same conviction (22:55) Why does he holds two titles at once? (25:17) Why Silicon Valley glorifies the wrong founders (27:52) Building an AI-native hospital (30:20) Managing funds through bubbles & hype cycles (33:13) How funds sell ownership stakes (34:59) Why the software buyout model is broken (38:44) Vista's new software buyout debt fund (39:20) Global Resilience vs. American Dynamism (41:49) GC’s $5B bet on India (45:48) What global investing teaches you (47:09) The four forces of tech lash (50:12) Anthropic, Mythos & the Pentagon (54:06) Is GC going public? (55:26) The Puka shell necklace era

I've been posting less and writing more. I've found it helpful to slow everything down and take the time for proper reflection. Today I'm putting out a review of the last quarter: Growing AI Anxiety Turning LLMs into Computers Anthropic and the Department of War Iranian Conflict The Incoming Techlash It's easy to feel like the response to this is for tech to "get tough" But I want to encourage the next generation to do something simple: keep your soul

“If we’re going to bend the cost curve in healthcare and change the way people access care, we need to reimagine things from first principles. That’s what got us to where we are today: we’re an operating system for health plans.” We are leading @YuzuHealthInc's $35M Series A to help catalyze more innovation in health insurance. Congrats to @maxkauderer, @up_to_nonsense, @EryDayImRusslen and the team. Watch GC's Alex Tran in conversation with Max and Ryan.

Navy submarine officer turned founder @CameronLMcCord: "When you're 484 days underwater, you need to feel motivated and understand how what you're doing plays into a bigger picture. That's something I always try to do at @Nominal_io." The bigger picture is global resilience. Nominal is the infrastructure for the teams building for the physical world. We led Nominal's Series A and are doubling down on their $80M round led by @foundersfund at a $1B valuation. All systems Nominal. Watch GC's Paul Kwan in conversation with Cameron.

This is not politics as usual. As investors, innovators, leaders, and citizens, we need to come together to preserve our democracy, the rights set forth in our country's Constitution, and our shared humanity. All of these serve as the foundation for our modern society, human progress, and innovation. What we are seeing in Minnesota is a threat to those core tenets and to the promise of America. Without confidence in the fundamentals -- human rights, the legal process, and the privilege and responsibility of our government and its leaders to protect all people -- the future is at stake. That impacts all of us here in the U.S., and globally.