Cancer patients with the same diagnosis often have very different tumor biology. Molecular testing can reveal underlying differences, but that's slow and expensive. Introducing Holon-S1, our platform to predict genes and biomarkers from routine pathology slides. • beats two other models at predicting spatial gene activity in a controlled comparison • has identified potentially novel biomarkers in breast cancer and colon cancer • evaluated across 16 organ types and more than 15 scanners, using slides from both formalin-fixed, paraffin-embedded and fresh-frozen tissue. We believe Holon-S1 has the potential to help researchers find new biomarkers in slides they already have, discover treatment targets, and bring more personalized cancer care within reach!

It's fine to criticize Terence Tao's statements. I did! But some people have taken it too far, calling him names and saying he's not intelligent. That's stupid. Terence Tao is obviously among the most intelligent people alive and one of the greatest living mathematicians!

Terrence Tao is obviously extremely smart but he also clearly doesn't know anything about drug development. This is literally how it works now. The mechanism of action of many drugs, including chemotherapy drugs, are poorly understood. We don't even know how Tylenol works! Additionally all these drugs have tons of off-target side effects. In a sense most drugs are "misaligned"!

+100! The conference needs to be in one location, that location should be easily accessible visa- and travel-wise. The whole point is cross-pollination, serendipitous encounters, catching up with old friends. Several locations at the same time (!) is promoting the opposite.

My hot take is having three locations for a conference doesn't make any sense. The whole point of conferences is to be for everyone to gather together and share ideas and have insighful conversations. By splitting up the conference, there is less ability to do this!