Register and share your invite link to earn from video plays and referrals.

Jay Rughani
@JayRughani
Partner @a16z leading investments in health technology. Prev @flatironhealth (acq by @roche for ~$2b) & @deloittehealth. Professional student.
988 Following    6.9K Followers
"I only had 5 minutes to read your (medical) chart" @gdb shares a story of his friend in the hospital. @ChatGPT flagged an antibiotic that could have killed her. Her doctor agreed: he missed a detail in her medical history. Need more stories like this to keep the doomers at bay
Show more
Expanding a16z growth to invest in six big trends:
Our fifth growth fund is now $8.5b. The founder is the asset in late stage, and we back the best in the world. At the same time, the best founders face global complexity earlier in their lives than ever before. So we are building out an enhanced Growth Platform for these exceptional founders. Biggest product cycles of our lives. Never been higher stakes, and never been more excited. @a16z
Show more
New a16z fund to invest in the physical buildout of AI
$1.1B for the Machine Age.
Instinct got me primetime Odyssey IMAX tickets, and now I'm a user for life I think
A frequent topic of discussion and debate with founders these days: how to build a business that is both AI-Native and AI-Proof - one that takes full advantage of frontier models, and is also unlikely to be disrupted by frontier models? Wrote a synthesis of those discussions below... tl;dr the center of gravity of value is moving from (intelligence + automation) to (intelligence + automation + accountability).
Show more
if you want to work w/ an elite team of storytellers, creatives, and media savants, this is it
We're hiring again at New Media. Our team does storytelling for our firm and our companies (and in part, our industry) including working closely with SpaceX, OpenAI, and many others. We run many of the firm's networks and we also have a couple incubations in the works. We're focused on helping compound the competitive advantages of the firm. This quarter we’ve hired some great people: @gaby_goldberg @jessicarwolf @kareeening @thedanigrant @mikemcg0, @brookemrtn, @LukeDeNatale @rorhug, and a couple others to be announced. We’ve also spun out some great people who are working closely with us but from incubations or portfolio companies — the amazing @liangsays @netcapgirl @gbrl_dick @humford @davideoks @schisofrenia @ChrisJBakke @knowerofmarkets paving the way for more leadership opportunities on the team. For people who want to learn about operating and investing, for people who want to feel like they get the depth and camaraderie of a startup with the breadth and intellectual curiosity of a VC firm, it’s the perfect place. People here love the work, the people, and the growth–and we’re committed to this being a springboard for their career, as shown from the folks above. If you’re interested and a good fit, we’d love to meet - apply below. We’re also hosting a dinner Thursday. The best way to apply is via proof of work or a strong reference. Apply: Roles below: Chief of Staff: help me run all our initiatives at the intersection of investing, networks, and media. Senior role with a big impact. Marketing and Comms Leadership: own the narrative for the a16z portfolio and firm. We’re hiring a CMO and a Chief Comms Officer. Podcasts: run, produce, scale our podcasts end-to-end. We’re also looking for a podcast host for new podcasts and podcast researchers. Content: define the agenda for tech. Build the most well-read and high-taste tech publication in the industry as an editor, writer, or specialist in growth/operations. Social: build the biggest go-direct channels for the firm and top-tier CEOs, drive content strategy, design and audience growth. Portfolio services: forward deploy into our most important portfolio companies and help them solve zero-to-one marketing and media strategy problems. Research: help us curate the most important conversations in tech. Networks: Help build digital and IRL community across our extended networks of founders, investors, creators, and the tech ecosystem more broadly. Help run our VIP group chat operation. Help us source and identify amazing future founders at top companies today. College: help us build a network of talented young people on campuses across the country (and the world). Also, watch this space. Talent: Help our portfolio companies build their employer brands and build candidate-sourcing machines. Product and AI Engineer: Build the best products in house to help scale our work and networks Events: own flagship gatherings and summits that create moments people talk about. Video: we want to take flyers on creative directors, content generalists, and aspiring filmmakers in tech. More broadly, we’re interested in hiring anyone doing something exceptional at the intersection of investing and networks or content or product.
Show more
Self-driving cars are healthcare
FSD Supervised keeps you 7x safer on the road for about $3.33 a day Less than the avg cost of a coffee in the US
craziest part is that this cost ~$2,000
An internal version of Astra, @OpenAI’s next major model family, solved 10 major open problems in mathematics, quantum complexity, and theoretical computer science. We believe it will be a major step for scientific reasoning.
Show more
Symptoms of a healthcare labor crisis
AI medical care will be everywhere. @CounselHealth Studio layers it inside the apps you already use. Available in @ouraring today, more coming soon 👀
We're incredibly excited to announce Counsel Studio 🩺 A new deployment platform that brings AI-enabled, physician-supervised care directly into healthcare organizations' existing digital experiences. Health plans, health systems, and consumer health companies can now seamlessly integrate and white-label Counsel’s AI-enabled care model within their own applications.
Show more
input costs of medical ai apps falling quickly
Medicare now covers GLP-1s for obesity. Even outside of obesity, Medicare GLP-1 scripts hit ~22 million in 2024 (up 4x from 2019, double 2022). Now add the biggest indication of all (~20 million clinically eligible Medicare patients over time). Impact still underappreciated.
Show more
Pearl Health has $110M in new capital to accelerate its mission of empowering healthcare providers with AI tools to deliver better care at lower cost. We @a16z are leading their $50M equity financing, and Pearl has secured an additional $60M in debt financing. Today, @PearlHealth_ profitably manages $3.6B in healthcare spend across 10,000+ providers and 250,000+ Medicare beneficiaries in 40 states. It's been amazing to see their progress since we first invested in 2021. @vintweeta @CarolineGoggs @DavidGeorge83 @a16zBioHealth
Show more
3 ai product roles at @a16z-backed infinite healthcare startups: 1. counsel health [series a] — sr product manager, consumer 2. prosper ai [series a] — ai product manager 3. abridge [series e] — product lead, ai/ml dm for intros @CounselHealth @ProsperAI_HQ @AbridgeHQ
Show more
These numbers are actually crazy I love me a brilliant healthcare administrator, but our ratios are clearly just off (and getting more off) As @JayRughani and @janerheetweets write, may the AI agents please go forth and prosper... (s/o @ProsperAI_HQ)
Show more
Life sci industry runs billions in externalized R&D via spreadsheets. Crazy. Orchestra’s agents can dramatically increase our scientific throughput.
Many biotechs today don't have their own labs. Their team sits in an office orchestrating the work of CROs, CDMOs, and other external partners. What you gain in speed and cost you can lose in control. Today, AI agents can manage externalized R&D on your behalf.
Show more
Healthcare can’t hire fast enough. Job openings run ~2x hires, and the gap keeps widening. We can’t staff our way out of this. This is why we @a16z are leading Prosper’s $30M Series A, and I am joining the board. Proud to back them with @janerheetweets and the @a16z team.
Show more
At Prosper AI we are thrilled to have raised a $30M Series A led by @a16z We’ve grown 5x in the last 6 months, supporting now +150,000 healthcare providers and 60+ healthcare organizations, including outpatient groups and enterprises backed by firms like Blackstone, KKR, and Bain Capital. Healthcare's most influential organizations, including @athenahealth , the largest EHR for outpatient practices, are now our customers. Prosper is the first AI platform to run the entire patient journey. 👇
Show more
We still spend ~2x more on cancer drugs than on diabetes + obesity drugs combined (~$143B vs. ~$72B, net). But those two areas added more spend last year than cancer did. Will they cross over one day?
Show more
I want to fund infinite healthcare apps. AI that delivers more care and less paperwork. Companies like @CounselHealth, @EvidenceOpen and @TennrOfficial are leading the way. If you are building this future, I would love to chat.
Show more
0
120
580
28
Forward to community