Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more:

I've been working on this for 3 months, and here it is: My iOS and iPadOS 27 review: Customizable Liquid Glass, iPadOS, 15 system apps, and a big Siri AI chapter. And no, it's not a Snow Leopard release. Enjoy!

✨ New iPhone Duo workshops drop happening around the world! These are running from Sep-Nov, and check back for updates to the list! ☀️Cupertino 🍎NYC 🌴Miami 🇫🇷Paris 🇬🇧London 🇩🇪Berlin 🇮🇳Bengaluru 🇨🇳Shanghai

GPT-6 Sol and Luna are out, and they are better AND 50% cheaper than 5.6. Luna is now $0.10 input / $0.50 output per 1M tokens. This is on top of the 80% price cut to Luna we made at the end of July. Output went from $6 -> $0.50 within two months.

We’re also launching Claude Sonnet 5.5 and Haiku 5.5 in the coming weeks. These models will come with many of the same improvements to performance, efficiency, and safety. With that, happy building everyone.

Update: I have joined Notion! After building Mocha, I look at companies and work very differently. I have an extremely high bar which Notion exceeds in multiple aspects. First of all, how many products do you use every day and love using? For me there are roughly 5: my iPhone with its core iOS apps, Notion, and maybe Spotify. I also use AI products (Claude, Grok Bot, Muse...) but those seem to rotate a lot. It feels like a privilege to be able to work on something that's so special to me and so many others. Notion’s mission resonates strongly with my personal ethos, and has a lot of common ground with what I was building at Mocha: “Empowering people to build beautiful tools for their life’s work” through the medium of malleable software. Yep, sounds pretty awesome to me! Our tools are changing faster than ever, mostly in exciting ways but sometimes in scary ways. At Notion they (we!!) believe our tools shape us, and we should build tools which keep humans collaborating and thinking together. I agree very strongly and want to make sure we build a good future. Notion’s team is so stacked! I had a good opinion of them before talking with them, but after speaking with them I was surprised. Every single person I interacted with impressed me, and made me want to build stuff with them. It’s rare to have such talent density. I’m so excited to work with @geoffreylitt @mschoening @brian @nbaschez @colebemis and many others that I can’t mention here. The company is very founder-led and intentional. Sometimes when a company is 13 years old, the founders are checked out. Not here. @ivanhzhao is deeply involved in the product and company, @akothari is constantly trying to improve how Notion can be better explained to the world, and @simonlast has consistently been building at the tip of the AI frontier since before chatGPT came out. A lot of founders sort of “luck into” their domain. If they lived 10 parallel lives, they wouldn’t build the same company 10 times. But some founders would, and I believe Ivan is one of these founders. This means the culture is very intentional: how people communicate, how they work together, how the office is decorated, how they build product, etc… This means that if you are a good fit for the culture, you’re a really good fit. I think it's why so many ex-founders end up here and love it. Finally and importantly: I think Notion is in an incredibly underrated position in the AI race. There is so much competition at the provider level, and although I love the products I feel little to no affiliation or loyalty to model providers. Notion on the other hand is like the comfy data backpack i bring with me when i go from grok bot to muse to instinct, from claude code to codex, etc… It’s the “AI switzerland” which gives people and companies freedom and power to own their own context layer. I think this matters a lot! I’m grateful and honored to be brought into this special team. I’m staying close to my roots and will be building AI products. We're already shipping some big improvements to the harness and custom agents, and there are many very cool improvements coming. I'll be sure to share what we ship along the way, so follow along! Please share feedback and tell me how you use Notion, what we can improve, what you wish it did better, and I’ll do my best to help make it happen!