Patrick Joyce
@joycesticks
A tube within a tube. Co-founder & COO @ResearchHub
809 Following 1.9K Followers
Tbh so proud to be backed by @BoostVC - these guys have their finger on the pulse of America! Be the cockroach!
This week @ResearchHubF handed the simulated fly brain $100 of RSC and turned open proposals into smells
The connectome under it came out this month from @HHMIJanelia and @GoogleResearch
It put all 100 ethereum:0xd101dcc414f310268c37eeb4cd376ccfa507f571 on one proposal - so I decided to join it by donating 10k of my own!
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A 2019 study out of Australia found that the effort burned applying for grants can outweigh the value distributed by an RFP 🤯
Nobody should lose a month on a doomed application
Pretty cool use of AI here from @researchhub to help make the application process more efficient
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Thanks to @Delyea_Cole I just funded: Predicting CD8⁺ T-Cell Proteomic-derived Regulatory States from Low-Plex Immunofluorescence on ResearchHub!
There are always signs that you’re a founder.
The future of scientific publishing was the focus of a great session at the #NAD# #neuroscience# Workshop this week! We discussed #OpenAccess#, @ResearchHub, peer review, #PeerReplication#, research integrity, #reproducibility#, and #AI# in #publishing#. Thanks to our fantastic panel!
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I remember the first few days of Figshare, we would get excited when someone made "something" openly available
Its now about 3,000 items/day being made open across Figshare infrastructure
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hockey players rejoice
We're seeing one of the most active research crowdfunds on ResearchHub right now.
@UmaRChatterjee's OCD proposal has attracted 29 funders and is nearly 60% funded. But what's been most exciting is everything happening around the fundraiser.
→ Regular video updates from the lab.
→ Public discussion with the community.
→ Expert and AI peer reviews.
→ Scientists and funders engaging throughout the campaign.
This is open science in action: research funded, reviewed, and discussed in public.
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Scientific impact is hard to measure, but it's key to funding the best science. How can we better predict and reward impactful research? Send your input through our Request for Information on Measuring and Rewarding Scientific Impact by August 19. #RFI#
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Jacob Stern, the lead behind Sid's research effort, walked through their therapeutic strategy at Catalyst NYC last month which included single-cell sequencing, custom mRNA vaccines, personalized CAR-T and TCR-T cells, and radioligand therapy.
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Could geopolymers help solve some of humanity’s biggest challenges?
@UofIllinois professor Dr. Trudy Kriven believes they have enormous potential.
Earlier this year, her lab received $100,000 in funding through ResearchHub to advance its work. But discovering a scientific pathway is only the beginning. Turning it into real-world impact takes collaboration.
As Dr. Kriven puts it:
“We’re just academics. We find a scientific pathway. But it needs more teamwork. It needs people really interested in doing it on a large scale.”
The science is promising. The next challenge is bringing together the people who can help scale it.
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I just funded: Breaking the OCD Loop: How Genes Disrupt Brain Connections–and How We Can Fix Them on ResearchHub!
The Interstate Power Observatory is funded: $1,000 on @ResearchHub, three weeks early.
Thanks to @joycesticks, @jeffyfish9, @TylerDiorio, and Xavier Pereira Hernandez for your support!
Per the pre-registration, the @ManifoldMarkets forecasts close Aug 7, and only then does the analysis run. Odds are live now:
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A recent study found that poor sleep and depression share a common profile that can be predicted, in part, by everyday lifestyle factors.
Eight experts have peer reviewed the preprint on ResearchHub, giving it an average score of 3.5/5 ⭐️
𝗧𝗵𝗲 𝘀𝘁𝗿𝗼𝗻𝗴𝗲𝘀𝘁 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝗼𝗿𝘀:
• Rarely confiding in others
• Too much sedentary TV time
• Low physical activity
• Secondhand smoke exposure
The model held up across independent datasets, including patients with clinical depression, suggesting these modifiable factors could be useful targets for prevention.
Join the discussion on ResearchHub →
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You emit light.
Expanding biology beyond molecules allows us to consider another layer of life: how energy, including light, may reflect and perhaps help coordinate biological activity.
Thank you to @JoMarchant and @Nature for featuring our work alongside other leaders in the field, and for opening a broader conversation about what might be possible, the tools we must build, and the next generation of scientists we must train.
Now, we have the opportunity to determine what the light of life is telling us.
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🎥 Meet Kenan, the researcher behind a live ResearchHub proposal.
Nearly every case of ALS involves a protein called 𝘛𝘋𝘗-43, but scientists still don’t fully understand how it drives disease.
In this video, Kenan explains how his lab discovered something unexpected in a fruit fly model: inflammation doesn’t stay where the neurons are damaged. It appears to spread throughout the body.
His team at @EPFL is now investigating 3 key questions:
1. What’s carrying the inflammatory signal?
2. Which receptors are detecting it?
3. Could reducing this peripheral inflammation help slow disease progression?
Support Kenan's research →
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Next month, every line of code touching the 𝕏 system will be open source and third-party audited.
Only total transparency deserves trust.
I've always thought ResearchHub was cool, in a super non-traditional way. It's the kind of thing young scientists get excited about, but old guys probably get confused by.
Then a White House report outlined an oddly similar vision.
Did DeSci just go mainstream?👀
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Science needs more players. 🧬🚀
SciCon Shooter is a community-built arcade space shooter where you battle enemy formations, take on evolving bosses, collect upgrades and climb the weekly leaderboard.
Each week, the top player receives 100 RSC Funding Credits to award to a live proposal on @ResearchHub
Play the game. Set the high score. Help fund real science.
Major gameplay updates are live 👇
🎮 Play link in the first reply.
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